For patients receiving chemotherapy, radiation therapy, or surgery

ZUPLENZ HELPS PREVENT TREATMENT-RELATED NAUSEA AND VOMITING

ZUPLENZ (pronounced ZOO-plenz) helps in the prevention of:

  • Nausea and vomiting associated with highly emetogenic cancer chemotherapy in adults
  • Nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy in adults and children aged 4 years and older
  • Nausea and vomiting associated with radiotherapy in patients receiving total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen in adults
  • Postoperative nausea and/or vomiting in adults

IMPORTANT SAFETY INFORMATION

  • Before you take ZUPLENZ, tell your healthcare provider if you: have any heart problems, including a condition called "congenital long QT syndrome" or take a medicine that causes heart problems (QT prolongation), have liver problems.
  • Patients with severe hepatic impairment (Child-Pugh score of 10 or greater) should not receive more than 8mg of ZUPLENZ per day due to a reduction in drug clearance.

How ZUPLENZ works

ZUPLENZ is a Minty, unique, micro-thin film strip THAT CONTAINS ONDANSETRON

ZUPLENZ is a formulation of ondansetron, a medicine prescribed millions of times each year to prevent nausea and vomiting related to chemotherapy, radiation therapy, or surgery. Ondansetron works by blocking some of the chemicals that are released from the brain and the intestines that cause you to feel sick and vomit. ZUPLENZ offers flexibility—it may be taken with or without food or water. Unlike some other medications for nausea and vomiting, it works without making you drowsy.

ZUPLENZ offers a minty, non-gritty alternative for people who have difficulty swallowing

Some people receiving cancer therapy may have a hard time swallowing pills due to side effects of cancer treatment, like dry mouth or sores in the throat. Similar to a breath-freshening strip, ZUPLENZ dissolves in seconds without water, so it helps provide control of nausea and vomiting without the need to swallow with water or waiting for a gritty pill to dissolve.

How to use ZUPLENZ

ZUPLENZ: Designed to help make treatment more comfortable

ZUPLENZ strips are individually wrapped and can be taken almost anywhere

Whether you are on your way to treatment, visiting family, or heading to the park, individually wrapped ZUPLENZ strips allow for discreet, “on-the-go” administration of the leading agent prescribed to help prevent nausea and vomiting.

ZUPLENZ is flexible; the non-gritty film strips can be used with or without water. If you forget to take your dose at home, you have the freedom to take ZUPLENZ on the go.


IMPORTANT SAFETY INFORMATION

  • ZUPLENZ may cause serious side effects, including severe allergic reactions. Stop taking ZUPLENZ and get medical help right away if you have any of these signs or symptoms of an allergic reaction to ZUPLENZ: rash, hives, itching, trouble breathing, chest tightness or chest pain, swelling of your mouth, face, lips, or tongue.

Nausea and vomiting are common side effects of chemotherapy and radiation

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ZUPLENZ is a medicine to help prevent nausea and vomiting in patients receiving chemotherapy, radiation therapy, or surgery

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Helpful resources for coping with nausea and vomiting during cancer treatment

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IMPORTANT SAFETY INFORMATION

  • Do not take ZUPLENZ if you: take apomorphine hydrochloride (eg, Apokyn®), have had an allergic reaction to ZUPLENZ or ondansetron or are allergic to any of its ingredients. See the last page of the full Patient Information.
  • ZUPLENZ may cause serious side effects, including severe allergic reactions. Stop taking ZUPLENZ and get medical help right away if you have any of these signs or symptoms of an allergic reaction to ZUPLENZ: rash, hives, itching, trouble breathing, chest tightness or chest pain, swelling of your mouth, face, lips, or tongue.
  • Before you take ZUPLENZ, tell your healthcare provider if you: have any heart problems, including a condition called "congenital long QT syndrome" or take a medicine that causes heart problems (QT prolongation), have liver problems.
  • Patients with severe hepatic impairment (Child-Pugh score of 10 or greater) should not receive more than 8mg of ZUPLENZ per day due to a reduction in drug clearance.
  • The most common side effects of ZUPLENZ include: headache, tiredness and body discomfort, constipation, diarrhea. These are not all the possible side effects of ZUPLENZ. For more information, ask your doctor or pharmacist.
  • Taking ZUPLENZ with certain other medicines may cause serious side effects. Tell your doctor about all prescription and over-the-counter medications and supplements you take, including apomorphine (for Parkinson's/movement disorders), tramadol hydrochloride (for pain), medicines for depression and migraine, and any other medicine for nausea and vomiting.

You are encouraged to report negative side effects of prescription medical products to the FDA.
Visit www.fda.gov/safety/medwatch, or call Fortovia at 1-855-273-0468.

Please see full Prescribing Information.

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IMPORTANT SAFETY INFORMATION

  • Do not take ZUPLENZ if you: take apomorphine hydrochloride (eg, Apokyn®), have had an allergic reaction to ZUPLENZ or ondansetron or are allergic to any of its ingredients. See the last page of the full Patient Information.
  • ZUPLENZ may cause serious side effects, including severe allergic reactions. Stop taking ZUPLENZ and get medical help right away if you have any of these signs or symptoms of an allergic reaction to ZUPLENZ: rash, hives, itching, trouble breathing, chest tightness or chest pain, swelling of your mouth, face, lips, or tongue.
  • Before you take ZUPLENZ, tell your healthcare provider if you: have any heart problems, including a condition called "congenital long QT syndrome" or take a medicine that causes heart problems (QT prolongation), have liver problems.
  • Patients with severe hepatic impairment (Child-Pugh score of 10 or greater) should not receive more than 8mg of ZUPLENZ per day due to a reduction in drug clearance.
  • The most common side effects of ZUPLENZ include: headache, tiredness and body discomfort, constipation, diarrhea. These are not all the possible side effects of ZUPLENZ. For more information, ask your doctor or pharmacist.
  • Taking ZUPLENZ with certain other medicines may cause serious side effects. Tell your doctor about all prescription and over-the-counter medications and supplements you take, including apomorphine (for Parkinson's/movement disorders), tramadol hydrochloride (for pain), medicines for depression and migraine, and any other medicine for nausea and vomiting.

You are encouraged to report negative side effects of prescription medical products to the FDA.
Visit www.fda.gov/safety/medwatch, or call Fortovia at 1-855-273-0468.

Please see full Prescribing Information.